DEPARTMENT OF LIFE SCIENCE
Life Science
Dr. Neesar Ahmed
 |
| Designation | : | Assistant Professor (Sel. Gr.) |
| Nature of Employment | : | Regular |
| Qualification | : | M.Sc. Ph.D |
| Phone | : | 044 22759215 Ext:215(Office) |
| Email ID | : | neesar.sls@crescent.education |
| Google Scholar link | : | https://scholar.google.com/citations?user=1cKYr1ZYh1YC&hl=en&oi=ao |
| Scopus Link | : | https://www.scopus.com/authid/detail.uri?authorId=55432664700 |
| OrcidId | : | https://orcid.org/0000-0002-7367-2188 |
Educational Background
- Ph.D (Biotechnology; Cancer Signaling) National Center for Cell Sciences (NCCS), Dept. of Biotechnology, Govt. of India, 2009, University of Pune, Pune, Maharashtra, India
- M.Sc (Biotechnology) Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh, India. 2004
- B.Sc (Biochemistry) Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh, India. 2002
Teaching and research Experience
- Associate Professor, BSA Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India, August 31, 2022 – till present
- Assistant Professor (Selection Grade) , BSA Crescent Institute of Science and Technology, Chennai Tamil Nadu, India, Feb 2020—August 30, 2022
- Assistant Professor, (Senior Grade) BSA Crescent Institute of Science and Technology, Chennai Tamil Nadu, India, Sep 2013-Feb 2020
- Post Doc Fellow (Cancer Immunology), Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, US, Jan 2011-Sep 2013
- Senior Research Fellow, National Centre for Cell Sciences (NCCS), Dept. of Biotechnology, Govt. of India, Pune, Maharashtra, India, 2007-2010
- Junior Research Fellow, National Centre for Cell Sciences (NCCS), Dept. of Biotechnology, Govt. of India, Pune, Maharashtra, India, 2005-2007
Honors and Awards
- University Grant Commission- National Eligibility Test (UGC NET-JRF/SRF)
- Qualified with fellowship in First Attempt-Joined National Center for Cell Sciences (NCCS), Dept of Biotechnology, Govt. of India, Pune for PhD.
- Department of Biotechnology, Govt. of India-fellowship during Post Graduation-Two Years (M.Sc.)
- GATE qualified in First attempt All India Rank-420
Research areas
- Cancer Biology
- Cancer Immunology
- Inflammation biology
- Tumor Microenvironment
- Protein Chemistry
- Lectins
Research outcomes
a. Research grants
Completed
PI Neesar Ahmed, DST-SERB Young Scientist Award (Rs. 25 Lakhs) 2014-2018 – completed
b. Publications
Number of Research Publications
International journals: 25
Invited talks delivered: 02
List of publications
- AK Bommanaboina, S Jamal, N Ahmed.* Antitumor Activity of Taxol Engross Taxol-Caveolin-1 Interaction via Lipid Raft Structure—“Caveolae”. Applied Biochemistry and Biotechnology. 1-12, 2023 (Scopus Indexed) (Index factor 3.09). https://doi.org/10.1007/s12010-023-04355-7
- M Basheeruddin, V Lavanya, N Ahmed, S Jamal*, Organic osmolyte betaine mitigates the deleterious effects of Diclofenac in vivo in wistar albino rats. Brazilian Journal of Pharmaceutical Sciences, 59, e201178, 2023, (Scopus Indexed) (Index factor 0.814). https:// doi: 10.3389/fmolb.2022.872905
- J Kashifa Fathima, V Lavanya, S Jamal, N Ahmed*. The Effectiveness of Various Chemotherapeutic Agents in Cancer Treatment. Current Pharmacology Reports, 1-17, 2022 (Scopus Indexed) (Index factor 1.524). https://doi.org/10.1007/s40495-022-00289-6
- M Gayathri, V Lavanya, S Jamal, N Ahmed*. Targeting Soluble Factors Involved in Inflammatory Cancer Microenvironment. Current Pharmacology Reports, 1-9, 2022, (Scopus Indexed) (Index factor 1.524). https://doi.org/10.1007/s40495-022-00291-y
- Basheeruddin, S Khan, N Ahmed, S Jamal*.Effect of pH on Diclofenac–Lysozyme Interaction: Structural and Functional Aspect. Frontiers in Molecular Biosciences 9, 2022(Scopus Indexed) (Index factor 6.113). https:// doi:10.3389/fmolb.2022.872905
- Logesh, V Lavanya, S Jamal, N Ahmed*. Designing of a Chimeric Vaccine Using EIS (Rv2416c) Protein Against Mycobacterium tuberculosis H37Rv: an Immunoinformatics Approach. Applied Biochemistry and Biotechnology 194 (1), 187-214, 2022 (Scopus Indexed) (Index factor 3.09). https://doi.org/10.1007/s12010-021-03760-0
- Lavanya, AK Bommanabonia, N Ahmed, S Jamal*. Immunomodulatory Effects of Jacalin, a Dietary Plant Lectin on the Peripheral Blood Mononuclear Cells (PBMCs). Applied Biochemistry and Biotechnology, 194 (1), 587-599, 2022 (Scopus Indexed) (Index factor 3.09). https://doi.org/10.1007/s12010-021-03722-6
- V Lavanya, S Jamal*, N Ahmed. Increased ERK phosphorylation and caveolin-1 expression on K562 human chronic myelogenous leukemia cells by jacalin, a dietary plant lectin. Glycoconjugate Journal 38 (3), 361-368, 2021 (Scopus Indexed) (Index factor 3.009). https://doi.org/10.1007/s10719-021-09998-4
- M Chandhru, R Logesh, S Kutti Rani, N Ahmed, N Vasimalai .Green synthesis of silver nanoparticles from plant latex and their antibacterial and photocatalytic studies. Environmental Technology, 1-11, 2021 (Scopus Indexed) (Index factor 3.475). https:// doi: 10.1080/09593330.2021.1914181
- Chandhru, R Logesh, SK Rani, N Ahmed, N Vasimalai. One-pot green route synthesis of silver nanoparticles from jack fruit seeds and their antibacterial activities with Escherichia coli and salmonella bacteria. Biocatalysis and Agricultural Biotechnology 20, 101241, 2019 (Scopus Indexed) (cite score 6.2). https://doi.org/10.1016/j.bcab.2019.101241
- AA Adil, AK Bommanabonia, A Vaithy, S Kumar, M Waseem, S Jamal, N Ahmed. Differential expression of Helios, Neuropilin-1 and FoxP3 in head and neck squamous cell carcinoma (HNSCC) patients. 3 Biotech 9 (5), 1-10, 2019 (Scopus Indexed) (Index factor 2.893). https://doi.org/10.1007/s13205-019-1707-7
- AAM Adil, L Vallinayagam, K Chitra, S Jamal, AK Pandurangan, N Ahmed. Increased Expression of TGF-β and IFN-γ in Peripheral Blood Mononuclear Cells (PBMCs) Cultured in Conditioned Medium (CM) of K562 Cell Culture. Journal of Environmental Pathology, Toxicology and Oncology 38 (2), 2019. (Scopus Indexed) (Index factor 3.567). https:// doi: 10.1615/JEnvironPatholToxicolOncol.2019029460
- V Lavanya, BA Kumar, S Jamal, MKA Khan, N Ahmed*. Sub-Micellar Concentration of Sodium Dodecyl Sulphate Prevents Thermal Denaturation Induced Aggregation of Plant Lectin, Jacalin. The Protein journal 36 (1), 17-27, 2017 (Scopus Indexed) (Index factor 4.00). https:// DOI 10.1007/s10930-017-9694-1
- V. Lavanya, Neesar Ahmed, Md Khurshid A. Khan & Shazia Jamal*. Sustained Mitogenic Effect on K562 Human Chronic Myelogenous Leukemia Cells by Dietary Lectin, Jacalin. Glycoconjugate Journal (2016), Volume 33, Issue 6, pp 877-886. (Scopus Indexed) (Index factor 3.009). https:// DOI 10.1007/s10719-016-9725-8
- Adil, V Lavanya, S Jamal, N Ahmed*. Cancer immunotherapy: Targeting immunosuppressive tumor microenvironment. Oncobiology and Targets 1 (1), 16-16, 2014.
- V Lavanya, AM Adil, N Ahmed, S Jamal*. Lectins-the promising cancer therapeutics. Oncobiology and Targets 1 (1), 12-12 (2014).
- V Lavanya, AM Adil, N Ahmed, S Jamal*. Small molecule inhibitors as emerging cancer therapeutics. Integr Cancer Sci Ther 1 (3), 39-46 (2014). https:// doi: 10.15761/ICST.1000109
Book Chapters
- The Multifaceted Role of Natural Agents in Colitis-Associated Cancer Prevention and Therapy. AKK Pandurangan, SK Anandasadagopan, N Ahmed. Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis (2021).
- Protagonist of Immuno-Profiling, Immuno-Scoring, and Immunotherapy Towards Colitis-Associated Cancer: Systematic Review M Adil, AK Pandurangan, M Waseem, N Ahmed
Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis. (2021). - Ubiquitin Mediated Posttranslational Modification of Proteins Involved in Various Signaling Diseases. V Lavanya, S Jamal, N Ahmed
Protein Modificomics, 109-130 (2019).
c. Research guidance
Ph.D
Graduated: 01, Ongoing: 02
List of Scholars completed
| S.No | Name of the scholar | Title of the thesis | Year of registration | year of Completion | Scholarship details | Outcomes |
|---|---|---|---|---|---|---|
| 1. | Dr. Adil Mohammed A A | Immunosuppresive cell within Tumor microenvironment | 2014 | 2019 | Maulana Azad National fellowship – UGC, India (2014-2019) | Publications:10 Conference presentations: 12 |
List of Scholars ongoing
| S.No | Name of the scholar | Title of the thesis | Year of registration | Year of Completion | Scholarship details | Outcomes |
|---|---|---|---|---|---|---|
| 1. | Anil B Kumar | Ubiquitin mediated regulation of the Inflammatory Tumor Microenviromnment in specialized lipid raft | 2015 | – | ICMR SRF | Publications:06, Conference presentations: 12 |
| 2. | Logesh R | Immunology of Mtb within macrophage | 2016 | – | ICMR SRF | Publications: 03, Conference presentations: 8 |
M.Sc/M.Tech
Completed projects: 27
Ongoing projects: 02
| S.No | Name of the student | Title of the project | Year of award | Outcomes |
|---|---|---|---|---|
| 1 | Anil K B | Immunomodulatory effect of jacalin purified from jack fruit seed | 2015 June | Conference presentations:2 |
| 2 | B. Famidha | Anti-inflammatory drug diclofenac induced structural and conformational change in Bovine serum albumin | 2016 May | Conference presentations:2 |
| 3 | Logesh | Immunomodulatory effect of LPS purified from diverse gram negative bacteria | 2016 May | Conference presentations:2 |
| 4 | Sakaram | “IMMUNOMODULATORY EFFECTS OF DIETARY LECTIN ‘JACALIN’ FROM JACKFRUIT (ARTOCARPUS INTEGRIFOLIA) SEEDS, ON HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS)” | 2017 May | Conference presentations:2 |
| 5 | Balaji Prasanna Kumar G | Increased expression of IL-2 and TGF beta in Jacalin stimulated human PBMCs and its effects on ME 180 cancer cells proliferation | 2019 May | Conference presentations:2 |
| 6 | S. Pavithra | Effcect of recombinant EIS protein in Mtb on bacterial culture and PBMCs proliferation | 2019 May | Conference presentations:2 |
| 7 | TS Priyadharshini | An overview of enhanced intracellular survival protein in mycobacterium tubercluosis | 2020 May | Conference presentations:2 |
| 8 | Dasarimanoj | In Silico characterization of Rv1477 gene product from mycobacterium tubercluosis | 2020 May | Conference presentations:2 |
| 9 | G Roni Mrudula | In Silico characterization of Rv0169 gene product from mycobacterium tubercluosis | 2020 May | Conference presentations:2 |
| 10 | J. Jerrina Marial | A Study on the effects of osmolytes on protein stability | 2021 July | Conference presentations:2 |
| 11 | Noornisha | Nanoparticle-based formulation, evaluation, and development of Facewash | 2021 July | Conference presentations:2 |
| 12 | S.Keerthana | Role of Caveolae in cell signaling | 2021 July | Conference presentations:2 |
| 13 | V.Krithika | Effect of temperature on the thermal denaturation of lectin crude lysate from green pea | 2021 July | Conference presentations:2 |
| 14 | Tesy Ranjana A | Insilico analysis of EIS (Enhanced Intracellular Survival Protein ) of Mycobacterium tuberculosis | 2021 July | Conference presentations:2 |
| 15 | Monica | Reveiw on Antibacterial activity of Vitex negundo against noscomial pathogens | 2021 July | Conference presentations:2 |
| 16 | D. Sudha | To study the stability and specificity of Jacalin: A dietary plant lectin | 2021 July | Conference presentations:2 |
| 17 | Aberna S | Combinatorial Chemotherapy of Taxol with methanolic extract of Allium cepa targeting breast cancer cell lines (MCF-7) | 2022 May | Conference presentations:2 |
| 18 | A.S. Faiza Fathima | Combinatorial Chemotherapy of Taxol with methanolic extract of Blue Beri targeting breast cancer cell lines (MCF-7) | 2022 May | Conference presentations:2 |
| 19 | Anitha M | Immunommodulatory and inhibitory effect of recombinant EIS protein from Mtb H37Rv | 2023 May | Conference presentations:2 |
| 20 | Yasmin Banu C | Extraction and characterization of active components of Ajwa Date Extract and its biological activities. | 2023 May | Conference presentations:2 |
| 21 | Vaishnavi S | Extraction and characterization of active components of Apple Extract and its biological activities. | 2023 May | Conference presentations:2 |
| 22 | S Keerthana | Effect of osmolytes glycine on jacalin-a plant lectin | 2023 May | Conference presentations:2 |
| 23 | K Asma | Effect of glycerol on the stability of jacalin(a plant lectin) | 2023 May | Conference presentations:2 |
| 24 | Pavithra A | Effect of Jacalin on Invitro tumor microenvironmentTME crosstalk between cancder and Immune Cells | 2023 May | Conference presentations:2 |
| 25 | Jhawahar M R | Characterization and Biological applications of Plectranthusamboinicus Leaf Extract | 2023 May | Publications:- Conference presentations:2 |
| 26 | Lucky Charan S | Biosynthesis of Iron oxide nanoparticles using Pisum sativum lectin extract and its biological application | 2023 May | Conference presentations:2 |
| 27 | Naveena R | Characterizing the physical and biological properties of lectins in Pisum sativum lysate | 2023 May | Conference presentations:2 |
B.Tech
Completed projects: 30
Ongoing projects :05
| S.No | Name of the student | Title of the project | Year of award | Outcomes |
|---|---|---|---|---|
| 1 | Yogeswari | Effect of Recombinant EIS (Rv 2416) protein of Mtb on Human PBMCs | 2018 June | Conference presentations: 2 |
| 2 | R Abirami | Analysis of Markers og Tregs on Human head & Neck squamous cell carcinoma | 2018 June | Conference presentations: 2 |
| 3 | ShadmaniAhrar | Purification and characterization of EIS protein involved in survival of Mtb in Macrophage | 2018 June | Conference presentations: 2 |
| 4 | Abeer | Role of Treg Cells and Association of FOXP3 and GATA 3 in TME | 2018 June | Conference presentations: 2 |
| 5 | Aamina Afshan | Cloning and expression of RpfB gene in Mtb | 2018 June | Conference presentations: 2 |
| 6 | Arvind Kumar Sharma | Insilico structural and functional characterization of Mtb gene RV1085c of H35Rv Strain | 2019 May | Conference presentations: 2 |
| 7 | Mohamed Adhnan P | Evaluation of AnticancerousProperity of SG extract & analysis of antagonist properties of small coumpound of SG Extract Against TLR4 | 2019 May | Conference presentations: 2 |
| 8 | Fathima H B | Glycine Inhibits Thermal Aggregation in rEIS protein | 2019 May | Conference presentations: 2 |
| 9 | N Balamurugan | To study the chemotheraphy induced adverse drug reaction in metastatic breast cancer | 2019 May | Conference presentations: 2 |
| 10 | Nada Rafat | Effect of soluble factors from cancer cell CM on PBMCs | 2019 May | Conference presentations: 2 |
| 11 | Mohseen Fathima S | Immunomolecular markers in Breast Cancer and Exploration of their role in Laboratory diagnosis | 2020 July | Publications: -Conference presentations: 2 |
| 12 | M Gayathri | TARGETING SOLUBLE FACTORS INVOLVED IN INFLAMMATORY CANCER MICROENVIRONMENT | 2020 July | Conference presentations: 2 |
| 13 | Kashifa Fathima J | COMBINATION OF NATURAL PRODUCTS WITH CHEMOTHERAPY AGAINST CANCER | 2020 July | Conference presentations: 2 |
| 14 | S Anuradha | Lectin Based Nanoparticles synthesis and its biological Applications | 2020 July | Conference presentations: 2 |
| 15 | Pradeepa A | isolation, Purification and functional analysis of Lectin from Kidney bean | 2020 July | Conference presentations: 2 |
| 16 | Abdullah Naveed Khan A | Ins Silico Characterization and structural prediction on Rv1884C (rpfC) gene product of Mycobacterium tuberculosis | 2021 July | Conference presentations: 2 |
| 17 | Aditya Subramanian V | In Silico design of multiepitope vaccine candidate against membrane protein (M Protein) of SARs CoV-2: An Immunoinformatic approach | 2021 July | Conference presentations: 2 |
| 18 | Harini R M | Topical pain relief medication using leaf of Morinda tinctoria and Eucalyptus globulus combination for arthritis patients-A review | 2021 July | Conference presentations: 2 |
| 19 | Nashiha Begum K | Effect of sulforaphane in variuos human diseases-A review | 2021 July | Conference presentations: 2 |
| 20 | Sadiya S | Effect of junk Food on human health | 2021 July | Conference presentations: 2 |
| 21 | Shobana. V.S | Molecular docking of Astaxanthin with incoprotein | 2021 July | Conference presentations: 2 |
| 22 | Supraja Tap | Green Synthesis of Zinc oxide nanoparticles using Solanum lycopersicum extract for breast cancer treatment: Insilico and in-vitro analysis | 2021 July | Conference presentations: 2 |
| 23 | Karishma. G.R | Anti-hepatotoxic effect of phytochemicals isolated from red lentil seeds (Lens culinaris) against HMGB1 protein: an insilico approach | 2021 July | Conference presentations: 2 |
| 24 | Mohammed Abdul Ahad. R | Properities and sourses of pectin to explore its Potential as an efficient food pacakging materials- A review | 2021 July | Conference presentations: 2 |
| 25 | Mumtaz Jabeen.A | Bebeficial aspects of indian spices | 2021 July | Conference presentations: 2 |
| 26 | Manu Sam | Extraction and study of the flavonoid quercetin from seeds and leaves of Trigonella foenum graecum | 2022 June | Conference presentations: 2 |
| 27 | Vaishnavi. S | Green synthesis, Characterization,Cytotoxicity and Anti inflammatory activity of Iron oxide nanoparticles | 2022 June | Conference presentations: 2 |
| 28 | Fathima Shifana SA | Decellularized based hydrogel from untanned leather wastes | 2023 May | Conference presentations: 2 |
| 29 | Gayathri R | Invitro Investigation of Anti-inflammatory, antioxidant activity and evalution of the phytochemical profile of Arthocarpushetrophyllus | 2023 May | Conference presentations: 2 |
| 30 | Falak Zohra | Effect of osmolytes on stability of recombinant EIS from Mtb H37v | 2023 May | Conference presentations: 2 |
